Sounds like some very simplistic judgements being made about a product & company that seem very sound & have a lot of credibility.

Uh huh.

Why not actually go to the web site & look at the ingredients & read the info first hand???

Uh... that's what I did. Do you think I just made the ingredients list up?

The enzymes work mainly on the liver,

Only if they make it into the bloodstream. If you eat them, you'll just digest them, like most other complex molecules you eat.

(Number of atoms in an ethanol molecule: Nine. Number of atoms in an alcohol dehydrogenase molecule: Thousands.)

If they're going to do anything, orally administered enzymes therefore have to do it to the alcohol with which they are sharing your GI tract, before the alcohol makes it to the bloodstream and before your own stomach acid and digestive enzymes have time to break the other enzymes down.

Had you read the other comments, you would know this. But that might interfere with your own very well-thought-out and entirely non-simplistic "judgements".

Taking half a glass of water every hour will also help to dillute & disperse any of the broken down alchol.

Taken literally, this statement is meaningless. Why would you care whether alcohol that's already been "broken down" is "dispersed" or not?

Taking a more charitable interpretation, drinking water along with your booze will help your hangover by itself, but moderate dilution of booze will, if anything, accelerate absorption of the alcohol.

Rockeby Biomed ... have a range of ground breaking new products.

Do they? Let's have a look!

Well, they've got PePP, plus a treatment for thrush, and test kits for HIV and bird flu. Those don't look especially ground-breaking to me, but what the hey.

They've also, however, got a treatment for "Systemic Candidiasis", a disease that even Doctor Weil calls an "unfounded diagnosis". If you've actually got yeast in your blood you're going to be very gravely ill, not buying some over-the-counter remedy because you're getting a lot of colds and feel a bit run-down.

Pepp pill have been proven to work...

By whom? How? When?

Has anybody, anywhere, ever shown oral administration of alcohol dehydrogenase to be of value?

And, once again - what on earth is the point of taking something that'll eat the alcohol in your stomach, if you're not a secret agent who needs to drink and stay sharp, or something?

A pill that clears alcohol and congeners and nasty metabolites from your system when the night is over would unquestionably be handy. And if it were possible for the enzymes to pass undamaged into the bloodstream, they might perhaps then do some good. But we know for a fact that they will not do that.

So what we're left with is a pill that only even offers the possibility of eating some of the alcohol before it makes it to your bloodstream. Which, clearly, will do nothing that just drinking less in the first place wouldn't do.

If you're not going to get the fun of the drug, why take it?

http://www.rockeby.com/ Check them out for yourself.

Please dont just bag people & products without any real conviction or just creating simplistic answers to complex processes & reactions that you have not studied.
Pepp pill have been proven to work.... if you cant afford them dont buy them. =)

Also, with respect to alcohol metabolism, the enzymes used (alcohol- and aldehyde- dehydrogenase) are both saturable (ie. can only cope with a certain amount of alcohol per hour), plus compete to metabolise other ingested compounds. (The famous one being methanol, with which ethanol competes for metabolism).

The rate-limited nature of alcohol metabolism (10g alcohol per hour) means you'd need to add a significant amount of enzyme to metabolise a gastric "load" of alcohol in quick enough time, prior to the alcohol all being absorbed.

ie. to metabolise 2 standard drinks you'd need to have both twice the amount of alcohol dehydrogenase that's actually in your liver, present in your stomach. This assumes alcohol sits in your stomach for a full 1 hour, and that you take the tablets simultaneously. If you assume the alcohol starts being absorbed much more quickly (eg. takes only 1/2 an hour transit time in stomach), then you need 4 times as much alcohol dehydrogenase as is present in your liver.

These pills would start getting fairly big pretty quickly in order to be useful. The above doesn't take into account inactivation of the enzyme by the gastric environment, nor the fact that this catalysis is taking place in a low pH which may not favour the process as much as the neutral environment of the liver.

Of course, as you've suggested, it's more likely they've only included one of the dehydrogenase compounds.

Another possibility, rather than them having included alcohol dehydrogenase in their product, is if they'd included solely aldehyde degrogenase instead. As it's the acetaldehyde which makes you feel so awful when you've been drinking heavily, additional enzyme could at least help make you feel a it better. It would do nothing, though, to hasten the removal of alcohol from your blood stream per se. In any case, I'm not sure if this would be viable given that once alcohol has been metabolised to acetaldehyde in the liver, I don't think gastric metabolism would play a major role in detoxifying acetaldehyde to acetic acid.

Bottom line: if someone can come up with a pill that contains both enzymes in useful quantities - I'd be willing to bet that it would have some effect. That doesn't seem to be the case here though, does it...